En dash for small separate, em dash for large.
Hyphen for hyphenated words.
Minus sign for maths.
Typewriter double quotes
Left, right, top or bottom curly double quotes, depending on position (start, end) and language.
Double prime for inches.
Right curly quote for apostrophes but left then right curly single quote for when they are used in English similarly to double quotes.
Multiplication sign for maths and for cross collaborations. Instead of letter x.
Ellipsis instead of three dots.
Then the only possible automatic thing would be unicode (many) to ascii (one), not the opposite.